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Fifth Doctor: Yes, less hungry, but also potentially more mentally unwell. Mounting reports of anxiety, worsening depression, and thoughts of suicide surround those taking GLP-1s, drugs like Ozempic. While it might be rare that the drugs make you go crazy, the potential troublesome psychiatric effects added to the long list of nasty physical effects makes the treatment intolerable for most patients. These effects are so severe that most patients stop taking the drug and thus a trial of these drugs becomes an expensive failed experiment for most people.